Wood I B, Amaral N K, Bairden K, Duncan J L, Kassai T, Malone J B, Pankavich J A, Reinecke R K, Slocombe O, Taylor S M
Department of Veterinary Parasitology, Veterinary School, Glasgow, UK.
Vet Parasitol. 1995 Jun;58(3):181-213. doi: 10.1016/0304-4017(95)00806-2.
The first edition of the W.A.A.V.P. anthelmintic guidelines for ruminants was published in 1982. Since then improved parasitological procedures have been developed, new therapeutic and prophylactic products have appeared requiring different test methods, and registration authorities are requesting more detailed record keeping and data validation. This second edition addresses these developments and fulfills the original goal of publishing guidelines for high quality, scientifically valid testing standards for trials that would be accepted as proof of efficacy by registration authorities regardless of country of origin. This second edition includes updated guidance on standard parasitological procedures, dose titration, dose confirmation and clinical trials, and provides guidelines for evaluating products for efficacy against anthelmintic resistant parasites, persistence of activity and prophylactic activity. Tests for efficacy against nematodes, trematodes and cestodes are included.
反刍动物蠕虫病防治指南的第一版于1982年出版。自那时以来,寄生虫学检测方法不断改进,新的治疗和预防产品不断涌现,需要不同的检测方法,而且注册机构要求更详细的记录保存和数据验证。第二版涵盖了这些进展,并实现了最初的目标,即发布高质量、科学有效的试验检测标准指南,这些标准将被注册机构视为疗效证据,无论原产国是哪里。第二版包括标准寄生虫学检测程序、剂量滴定、剂量确认和临床试验的更新指南,并提供了评估产品对驱虫抗性寄生虫的疗效、活性持久性和预防活性的指南。其中包括对线虫、吸虫和绦虫的疗效测试。