喂食饱和脂肪和胆固醇对兔脂蛋白流动性的相对影响。

Relative effects of feeding saturated fats and cholesterol on fluidity of rabbit lipoproteins.

Berlin E, Shapiro S G, Young C

Lipid Nutrition Laboratory, Beltsville Human Nutrition Research Center, United States Department of Agriculture, MD 20705.

Comp Biochem Physiol A Comp Physiol. 1991;98(2):343-6. doi: 10.1016/0300-9629(91)90544-m.

Abstract

The effects of saturated fat and cholesterol on lipoprotein fluidity were tested in New Zealand white rabbits fed diets containing corn oil (CO) or cocoa butter (CB) with and without added 0.2% cholesterol. 2. Saturated fats had little effect on fluidity in any lipoprotein fraction. 3. Cholesterol feeding dramatically reduced fluidity in VLDL and LDL, but minimal change was noted in HDL. 4. Cholesterol-fed rabbits were hypercholesteroloemic throughout the 10-month study. 5. The rabbits became adapted to cholesterol feeding as VLDL became more fluid with time.

摘要

在喂食含玉米油（CO）或可可脂（CB）且添加或不添加0.2%胆固醇的日粮的新西兰白兔中，测试了饱和脂肪和胆固醇对脂蛋白流动性的影响。2. 饱和脂肪对任何脂蛋白组分的流动性影响很小。3. 喂食胆固醇显著降低了极低密度脂蛋白（VLDL）和低密度脂蛋白（LDL）的流动性，但高密度脂蛋白（HDL）的变化最小。4. 在整个10个月的研究中，喂食胆固醇的兔子出现高胆固醇血症。5. 随着时间的推移，极低密度脂蛋白变得更具流动性，兔子适应了胆固醇喂养。