Recio María-Carmen, Cerdá-Nicolás Miguel, Hamburger Matthias, Ríos José-Luis
Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain.
Planta Med. 2006 Jun;72(8):715-20. doi: 10.1055/s-2006-941507. Epub 2006 May 31.
A dichloromethane extract of Isatis tinctoria was tested in the adjuvant-induced arthritis model in rats. The extract (150 mg/kg p. o.) leads to a significant reduction of paw oedema. Radiographic, histological and clinical assessment confirmed reduced damage of cartilage and signs of inflammatory response in comparison to untreated control. No significant differences were observed in the tissular levels of cyclooxygenases 1 and -2, and of inducible nitric oxide synthase in Isatis treated and untreated animals. High dose treatment with Isatis extract for two weeks did not result in macroscopic lesions of the gastric mucosa.
对菘蓝的二氯甲烷提取物在佐剂诱导的大鼠关节炎模型中进行了测试。该提取物（口服150毫克/千克）可显著减轻爪部水肿。与未治疗的对照组相比，影像学、组织学和临床评估证实软骨损伤减轻且炎症反应迹象减少。在经菘蓝处理和未处理的动物中，环氧化酶1和-2以及诱导型一氧化氮合酶的组织水平未观察到显著差异。用菘蓝提取物高剂量治疗两周未导致胃黏膜出现肉眼可见的病变。
