McNamara Judith R, Warnick G Russell, Cooper Gerald R
Lipid Research Laboratory, New England Medical Center, Tufts University, Boston, MA, USA.
Clin Chim Acta. 2006 Jul 23;369(2):158-67. doi: 10.1016/j.cca.2006.02.041. Epub 2006 Mar 24.
The study of modern lipid chemistry began in the 17th and 18th centuries with early observations by Robert Boyle, Poulletier de la Salle, Antoine François de Fourcroy and others. The 19th century chemist, Chevreul, identified several fatty acids, suggested the name 'cholesterine' for the fatty substance in gallstones, coined the word 'glycerine', and showed that fats were comprised of glycerol and fatty acids. The 20th century brought many advances in the understanding of lipoprotein structure and function, and explored relationships between lipoproteins and disease states. The development of the ultracentrifuge and other lipoprotein separation techniques, and reagents for accurate, standardized quantitative measurement have steadily increased our understanding of the important role of lipoprotein metabolism in both healthy and disease states.
现代脂质化学的研究始于17和18世纪，罗伯特·波义耳、普莱蒂埃·德拉萨尔、安托万·弗朗索瓦·德富尔克鲁瓦等人进行了早期观察。19世纪的化学家谢弗勒尔鉴定出了几种脂肪酸，为胆结石中的脂肪物质提出了“胆固醇”这个名称，创造了“甘油”这个词，并表明脂肪由甘油和脂肪酸组成。20世纪在脂蛋白结构和功能的理解方面取得了许多进展，并探索了脂蛋白与疾病状态之间的关系。超速离心机和其他脂蛋白分离技术的发展，以及用于准确、标准化定量测量的试剂，不断加深了我们对脂蛋白代谢在健康和疾病状态中重要作用的理解。
