Heinzerling Keith G, Shoptaw Steven, Peck James A, Yang Xiaowei, Liu Juanmei, Roll John, Ling Walter
Integrated Substance Abuse Programs, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA.
Drug Alcohol Depend. 2006 Dec 1;85(3):177-84. doi: 10.1016/j.drugalcdep.2006.03.019. Epub 2006 Jun 5.
To conduct a 16-week, randomized, placebo-controlled, double-blind trial of two GABAergic medications, baclofen (20 mg tid) and gabapentin (800 mg tid), for the treatment of methamphetamine dependence.
Adults with methamphetamine dependence were randomized to one of three conditions for 16 weeks: baclofen (n = 25), gabapentin (n = 26) or placebo (n = 37). All participants attended clinic thrice weekly to receive study medication and psychosocial counseling, complete study assessments, and provide urine samples.
No statistically significant main effects for baclofen or gabapentin in reducing methamphetamine use were observed using a generalized estimating equation (GEE). A significant treatment effect was found in post hoc analyses for baclofen, but not gabapentin, relative to placebo among participants who reported taking a higher percentage of study medication (significant treatment group and medication adherence interaction in GEE model of methamphetamine use).
While gabapentin does not appear to be effective in treating methamphetamine dependence, baclofen may have a small treatment effect relative to placebo. Future studies evaluating the effectiveness of baclofen and other GABAergic agents for treatment of methamphetamine may be warranted.
开展一项为期16周的随机、安慰剂对照、双盲试验，以研究两种γ-氨基丁酸能药物巴氯芬（20毫克，每日三次）和加巴喷丁（800毫克，每日三次）对甲基苯丙胺依赖的治疗效果。
将患有甲基苯丙胺依赖的成年人随机分为三组，进行为期16周的试验：巴氯芬组（n = 25）、加巴喷丁组（n = 26）或安慰剂组（n = 37）。所有参与者每周到诊所三次，接受研究药物治疗和心理社会咨询，完成研究评估，并提供尿液样本。
使用广义估计方程（GEE）未观察到巴氯芬或加巴喷丁在减少甲基苯丙胺使用方面有统计学上的显著主效应。在事后分析中，相对于安慰剂，在报告服用研究药物比例较高的参与者中，发现巴氯芬有显著的治疗效果，但加巴喷丁没有（在甲基苯丙胺使用的GEE模型中有显著的治疗组和药物依从性交互作用）。
虽然加巴喷丁似乎对治疗甲基苯丙胺依赖无效，但相对于安慰剂，巴氯芬可能有较小的治疗效果。未来可能有必要开展评估巴氯芬和其他γ-氨基丁酸能药物治疗甲基苯丙胺有效性的研究。
