Jung Chan-Hee, Lee Won Young, Rhee Eun-Jung, Kim Se-Yeon, Oh Ki-Won, Yun Eun-Joo, Kim Sun-Woo
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyung-dong, Seoul, South Korea.
Arch Med Res. 2006 Jul;37(5):612-8. doi: 10.1016/j.arcmed.2006.01.003.
In spite of the increasing information that has recently been accumulated on the involvement of ghrelin and leptin in the control of energy balance, the relationship between ghrelin and leptin and the growth hormone (GH)-insulin-like growth factor 1 (IGF-1) axis in the pathological condition characterized by GH deficiency has been poorly clarified. Therefore, we performed this study to examine the correlation of the plasma levels of ghrelin and leptin with the anthropometric and biochemical markers in GH-deficient (GHD) adults as compared to their healthy cohorts.
In 60 male adults (GHD; n = 12, healthy control; n = 48, average age: 54 years), we investigated the correlations between the serum leptin and ghrelin levels with the anthropometric and biochemical factors in the control group, as compared to the GHD patients. The diagnosis of GH deficiency was made when peak response for serum GH was <5 microg/L to a GH-provocative test (L-dopa test). All subjects underwent assessment of waist circumference, body mass index (BMI) and percentage body fat for their body composition. Plasma ghrelin, leptin, insulin, GH and IGF-1 were measured.
Groups were matched for age, BMI, waist circumference and percent of body fat. Ghrelin and leptin levels were not significantly different between the two groups. There was no correlation between the peak GH level or the GHAUC and the ghrelin concentrations in the GHD subjects. Plasma leptin correlated positively with percentage of body fat, total cholesterol and LDL-cholesterol, but it had no correlation with the peak GH or area under the curve for growth hormone (GHAUC) in the GHD subjects. Plasma ghrelin concentrations were not correlated with the biochemical and anthropometric markers in the subjects with GHD, and ghrelin showed no significant differences in the GHD and control subjects. Leptin concentrations were positively correlated with body fat, but they were not correlated with the levels of either IGF-1 or GH in the GHD patients.
It is possible that ghrelin concentrations appeared normal in the GHD subjects because of the opposing influences of increased adiposity, which reduce ghrelin secretion, and GHD, which may increase it. Further studies are needed to clarify these controversies about the relation of ghrelin and leptin with the GH and IGF-1 levels.
尽管最近积累了越来越多关于胃饥饿素和瘦素参与能量平衡控制的信息，但在以生长激素缺乏为特征的病理状态下，胃饥饿素和瘦素与生长激素（GH）-胰岛素样生长因子1（IGF-1）轴之间的关系仍未得到充分阐明。因此，我们进行了这项研究，以检查与健康队列相比，生长激素缺乏（GHD）成年人体内胃饥饿素和瘦素的血浆水平与人体测量和生化指标之间的相关性。
在60名成年男性中（GHD组；n = 12，健康对照组；n = 48，平均年龄：54岁），我们研究了与GHD患者相比，对照组中血清瘦素和胃饥饿素水平与人体测量和生化因素之间的相关性。当血清GH对生长激素激发试验（左旋多巴试验）的峰值反应<5μg/L时，诊断为生长激素缺乏。所有受试者均接受了腰围测量、体重指数（BMI）和身体脂肪百分比的身体成分评估。测量血浆胃饥饿素、瘦素、胰岛素、GH和IGF-1。
两组在年龄、BMI、腰围和体脂百分比方面相匹配。两组之间的胃饥饿素和瘦素水平无显著差异。GHD受试者的GH峰值水平或GHAUC与胃饥饿素浓度之间无相关性。血浆瘦素与体脂百分比、总胆固醇和低密度脂蛋白胆固醇呈正相关，但与GHD受试者的GH峰值或生长激素曲线下面积（GHAUC）无相关性。GHD受试者的血浆胃饥饿素浓度与生化和人体测量指标无关，并在GHD和对照组受试者中无显著差异。瘦素浓度与体脂呈正相关，但与GHD患者的IGF-1或GH水平无关。
由于肥胖增加（减少胃饥饿素分泌）和GHD（可能增加胃饥饿素分泌）的相反影响，GHD受试者的胃饥饿素浓度可能看起来正常。需要进一步研究以阐明关于胃饥饿素和瘦素与GH和IGF-1水平关系的这些争议。
