Stylianou Charilaos, Galli-Tsinopoulou Assimina, Koliakos George, Fotoulaki Maria, Nousia-Arvanitakis Sanda
4th Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road Nea Efkarpia, 56403 Thessaloniki, Greece.
J Cyst Fibros. 2007 Jul;6(4):293-6. doi: 10.1016/j.jcf.2006.10.011. Epub 2006 Dec 28.
Ghrelin and leptin are hormones implicated in energy balance coordination and body weight regulation. There are conflicting data regarding the levels and role of leptin while ghrelin has not been studied in CF. The aim of this study was to investigate fasting serum ghrelin and leptin levels in CF adolescents as compared to healthy controls and analyze their association with body fat.
Fourteen CF adolescents having pancreatic insufficiency and twenty healthy adolescents were enrolled in the study. Diabetic patients were excluded. In all participants' height, weight, body mass index (BMI) and body fat % (BF %) were estimated. Ghrelin and leptin levels were determined after an overnight fast.
Weight, BMI and BF% were significantly lower in CF adolescents than those of controls. Fasting leptin levels in CF were significantly higher in CF patients (p=0.030), compared to controls and significantly lower in CF males as compared to CF females (p=0.01). Fasting ghrelin levels were significantly lower in CF males as compared to male controls (p<0.001) and comparable in females.
As the overall clinical outcome of CF patients is related to the nutritional status and body weight, the role of ghrelin and leptin in these patients needs to be elucidated.
胃饥饿素和瘦素是参与能量平衡协调和体重调节的激素。关于瘦素的水平和作用存在相互矛盾的数据，而胃饥饿素在囊性纤维化（CF）患者中尚未得到研究。本研究的目的是调查CF青少年与健康对照者相比的空腹血清胃饥饿素和瘦素水平，并分析它们与体脂的关系。
本研究纳入了14名患有胰腺功能不全的CF青少年和20名健康青少年。排除糖尿病患者。对所有参与者的身高、体重、体重指数（BMI）和体脂百分比（BF%）进行评估。在禁食过夜后测定胃饥饿素和瘦素水平。
CF青少年的体重、BMI和BF%显著低于对照组。与对照组相比，CF患者的空腹瘦素水平显著更高（p = 0.030），且CF男性患者的空腹瘦素水平显著低于CF女性患者（p = 0.01）。与男性对照组相比，CF男性患者的空腹胃饥饿素水平显著更低（p < 0.001），而女性患者的空腹胃饥饿素水平相当。
由于CF患者的总体临床结局与营养状况和体重有关，因此需要阐明胃饥饿素和瘦素在这些患者中的作用。
