Wang Leyu, Bao Jie, Wang Lun, Zhang Fang, Li Yadong
Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
Chemistry. 2006 Aug 16;12(24):6341-7. doi: 10.1002/chem.200501334.
To demonstrate their applications in biological and medical fields such as in immunoassays, magnetic separation of cells or proteins, drug or gene delivery, and magnetic resonance imaging, the template-free syntheses of water-soluble and surface functionalized magnetic nanomaterials have become essential and are challenging. Herein, we developed a facile one-pot template-free method for the preparation of amine-functionalized magnetite nanoparticles and hollow nanospheres by using FeCl(3)6 H(2)O as single iron source. These magnetic nanomaterials were characterized by TEM, SEM, XRD, and FTIR technologies. Their magnetic properties were also studied by using a superconducting quantum interference device (SQUID) magnetometer at room temperature. Then the amine-functionalized magnetite nanoparticles were applied to immunoassays and magnetic resonance imaging in live mice.
为了证明它们在生物和医学领域的应用，如免疫分析、细胞或蛋白质的磁性分离、药物或基因递送以及磁共振成像，水溶性和表面功能化磁性纳米材料的无模板合成变得至关重要且具有挑战性。在此，我们开发了一种简便的一锅法无模板方法，以FeCl₃·6H₂O作为单一铁源制备胺功能化磁铁矿纳米颗粒和中空纳米球。这些磁性纳米材料通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）、X射线衍射（XRD）和傅里叶变换红外光谱（FTIR）技术进行表征。还在室温下使用超导量子干涉装置（SQUID）磁力计研究了它们的磁性。然后将胺功能化磁铁矿纳米颗粒应用于活小鼠的免疫分析和磁共振成像。
