ITODYS, Université Paris 7-CNRS UMR 7086, 15, rue Jean-Antoine de Baïf, 75205 Paris Cedex 13, France.
J Colloid Interface Sci. 2010 Jan 15;341(2):248-54. doi: 10.1016/j.jcis.2009.09.043. Epub 2009 Sep 25.
Superparamagnetic iron oxide nanoparticles, Fe(3)O(4) and gamma-Fe(2)O(3), were produced by the so-called polyol process. In order to stabilize the particles in a physiological environment as potential contrast agents for Magnetic Resonance Imaging (MRI), the as-prepared particles were successfully transferred to an aqueous medium through ligand exchange chemistry of the adsorbed polyol species with the dopamine or the catechaldehyde. The ligands were able to participate in bidentate binding to the nanoparticles surface and to improve the stability of aqueous suspensions of the nanoparticles. Analysis was performed by various techniques including X-ray diffraction, transmission electron microscopy, infrared spectroscopy and thermal analysis. The results of magnetic measurements and initial in vitro magnetic resonance imaging essays are presented for the pre- and post-surface modified nanoparticles, respectively and discussed in relation with their structure and microstructure.
超顺磁氧化铁纳米粒子，Fe(3)O(4)和γ-Fe(2)O(3)，是通过所谓的多元醇法制备的。为了使颗粒在生理环境中稳定，作为磁共振成像（MRI）的潜在对比剂，通过吸附多元醇与多巴胺或儿茶醛的配体交换化学，将制备的颗粒成功地转移到水介质中。配体能够参与与纳米粒子表面的双齿配位，并提高纳米粒子水悬浮液的稳定性。通过各种技术进行了分析，包括 X 射线衍射、透射电子显微镜、红外光谱和热分析。分别对表面改性前后的纳米粒子进行了磁性测量和初步体外磁共振成像实验，并与它们的结构和微观结构进行了讨论。
