肝得健和青霉胺对乙醇中毒大鼠肝脏和大脑中某些氨代谢酶活性的影响。
The effect of Heparegen and D-penicillamine on the activity of some ammonia metabolizing enzymes in liver and brain of rats intoxicated with ethanol.
作者信息
Farbiszewski R, Holownia A, Chwiecko M, Pawlowska D
机构信息
Department of Inorganic and Analytical Chemistry, Medical Academy, Bialystok, Poland.
出版信息
Drug Alcohol Depend. 1991 Jan;27(1):69-72. doi: 10.1016/0376-8716(91)90088-g.
This paper reports data on the effect of two drugs: Heparegen (thiazalidine-4-carboxylic acid) and D-penicillamine on the blood ammonia concentration and on some ammonia metabolizing enzymes in liver and brain of rats intoxicated with ethanol. It seems, that both drugs decrease ammonia concentration and simultaneously elevate liver and brain glutamine synthetase activity. The effect of D-penicillamine on the nitrogen metabolism in the damaged liver appears to be more favorable than that of Heparegen.
本文报道了两种药物——肝得健（噻唑烷-4-羧酸）和D-青霉胺对乙醇中毒大鼠血氨浓度以及肝脏和大脑中一些氨代谢酶的影响。似乎这两种药物都能降低氨浓度，同时提高肝脏和大脑谷氨酰胺合成酶的活性。D-青霉胺对受损肝脏氮代谢的影响似乎比肝得健更有利。
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