慢性乙醇给药后大鼠肝脏和大脑中某些氨代谢酶活性的变化。

Changes in activities of some ammonia-metabolizing enzymes in the rat liver and the brain after chronic ethanol administration.

作者信息

Farbiszewski R, Hołownia A, Chwiećko M

机构信息

Department of Inorganic and Analytical Chemistry Medical Academy, Białystok, Poland.

出版信息

Biochem Med Metab Biol. 1988 Dec;40(3):219-24. doi: 10.1016/0885-4505(88)90122-3.

DOI:10.1016/0885-4505(88)90122-3

PMID:2906801

Abstract

The changes in the activities of ammonia-metabolizing enzymes in liver and brain after ethanol intoxication has been investigated in rats. After administration of ethanol 30% (w/v) 6g kg-1 for 4 weeks we found an increase in liver glutamate dehydrogenase and glutaminase activity. In brain tissue the glutaminase activity was significantly higher and glutamate dehydrogenase was significantly lower. Glutamine synthetase activity in liver and brain was practically unchanged. The reasons for these changes in the activities of some ammonia-metabolizing enzymes in liver and brain after ethanol ingestion have been discussed.

摘要

对大鼠乙醇中毒后肝脏和大脑中氨代谢酶活性的变化进行了研究。给予大鼠30%（w/v）乙醇6g/kg，持续4周后，我们发现肝脏中谷氨酸脱氢酶和谷氨酰胺酶活性增加。在脑组织中，谷氨酰胺酶活性显著升高，而谷氨酸脱氢酶活性显著降低。肝脏和大脑中的谷氨酰胺合成酶活性基本未变。本文讨论了摄入乙醇后肝脏和大脑中某些氨代谢酶活性发生这些变化的原因。