Fuchs D, Shearer G M, Boswell R N, Lucey D R, Clerici M, Reibnegger G, Werner E R, Zajac R A, Wachter H
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
AIDS. 1991 Feb;5(2):209-12. doi: 10.1097/00002030-199102000-00012.
Hematopoietic disturbances are common in patients with HIV-1 infection. Recent studies on immune activation markers such as neopterin demonstrate that HIV-1 infection is associated with chronic immune activation. We investigated a possible association between serum neopterin concentrations and blood cell counts (CD4+ T cells, white blood cells, platelets, red blood cells) and hemoglobin and hematocrit in 94 HIV-1-seropositive individuals [52 Walter Reed (WR) stage 1, 31 WR2, one WR5, and 10 WR6]. There were significant negative correlations between neopterin concentrations and CD4+ T cells, hemoglobin, hematocrit and platelets. These correlations were also significant if either only WR1 and WR2 patients or the entire set of data were considered for calculations. Thus, hematological abnormalities are associated with chronic immune activation in patients with HIV-1 infection. Large amounts of neopterin are released by human macrophages on stimulation with interferon-gamma (IFN gamma), and tumor necrosis factor alpha (TNF alpha) further enhances the effect of IFN gamma. Therefore, our data suggest that activated immune cells and specific cytokines such as IFN gamma and TNF alpha are involved inhibiting hematopoiesis.
造血功能紊乱在HIV-1感染患者中很常见。最近对诸如新蝶呤等免疫激活标志物的研究表明，HIV-1感染与慢性免疫激活有关。我们调查了94例HIV-1血清阳性个体（52例沃尔特·里德陆军医疗中心（WR）1期、31例WR2期、1例WR5期和10例WR6期）血清新蝶呤浓度与血细胞计数（CD4+T细胞、白细胞、血小板、红细胞）以及血红蛋白和血细胞比容之间可能存在的关联。新蝶呤浓度与CD4+T细胞、血红蛋白、血细胞比容和血小板之间存在显著的负相关。如果仅考虑WR1和WR2期患者或全部数据集进行计算，这些相关性也很显著。因此，血液学异常与HIV-1感染患者的慢性免疫激活有关。人类巨噬细胞在受到γ干扰素（IFNγ）刺激时会释放大量新蝶呤，而肿瘤坏死因子α（TNFα）会进一步增强IFNγ的作用。因此，我们的数据表明，活化的免疫细胞以及诸如IFNγ和TNFα等特定细胞因子参与了对造血的抑制作用。
