小鼠的双重感染：内脏幼虫移行症与日本脑炎病毒的亚致死感染。

Dual infections of mice: visceral larva migrans and sublethal infection with Japanese encephalitis virus.

作者信息

Pavri K M, Ghalsasi G R, Dastur D K, Goverdhan M K, Lalitha V S

出版信息

Trans R Soc Trop Med Hyg. 1975;69(1):99-110. doi: 10.1016/0035-9203(75)90018-8.

Abstract

Experiments in 3 weeks old albino mice with Toxocara canis and sublethal infection with JE virus established a marked synergestic effect in dually infected mice. The results are discussed to indicate the possible role of visceral larva migrans in creating exploxive outbreaks of "acute encephalopathy syndrome" in individuals having simultaneous infection with a virus (es) which, alone, might produce only mild illness. The nature of the possible mechanisms involved yet remains to be understood.

摘要

用犬弓首蛔虫对3周龄白化小鼠进行实验，并对其进行日本脑炎病毒亚致死感染，结果显示双重感染的小鼠有明显的协同效应。对结果进行了讨论，以表明内脏幼虫移行症在同时感染一种（或多种）病毒的个体中引发“急性脑病综合征”爆发流行的可能作用，而这些病毒单独感染时可能只会导致轻微疾病。其中涉及的可能机制的本质仍有待了解。