Koo E H, Park Y C, Lim S H, Kim H Z
Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, Guro Hospital, Seoul, South Korea.
J Int Med Res. 2006 Mar-Apr;34(2):140-51. doi: 10.1177/147323000603400203.
Both ischaemic preconditioning (IPC) and amiodarone protect against myocardial ischaemia. We examined whether a combination of IPC and amiodarone demonstrated an additive protective effect in isolated rat hearts (n = 40). The controls (group I) were subjected to ischaemia/ reperfusion injury; group II was subjected to cycles of IPC prior to ischaemia/ reperfusion injury; group III was subjected to ischaemia in the presence of amiodarone (10(-10) mol/1); and group IV was subjected to IPC followed by ischaemia in the presence of amiodarone (10(-10) mol/l). Amiodarone produced the best preserved left ventricular end-systolic pressure and dP/dtmax, less developed ventricular stiffness, the shortest arrhythmia duration, and the smallest infarct size among the groups. All of the myocardial protective effects against ischaemia/reperfusion injury were diminished or abolished when IPC and amiodarone were applied sequentially.
缺血预处理（IPC）和胺碘酮均可保护心肌免受缺血损伤。我们研究了IPC与胺碘酮联合应用是否对离体大鼠心脏（n = 40）具有相加保护作用。对照组（I组）接受缺血/再灌注损伤；II组在缺血/再灌注损伤前进行IPC预处理；III组在存在胺碘酮（10⁻¹⁰ mol/L）的情况下进行缺血处理；IV组先进行IPC，然后在存在胺碘酮（10⁻¹⁰ mol/L）的情况下进行缺血处理。在各组中，胺碘酮使左心室舒张末期压力和dP/dtmax保存最佳，心室僵硬度发展较小，心律失常持续时间最短，梗死面积最小。当IPC和胺碘酮序贯应用时，所有针对缺血/再灌注损伤的心肌保护作用均减弱或消失。
