Dursun H, Bilici M, Uyanik A, Okcu N, Akyüz M
Department of Gastroenterology, Ataturk University, Medical School, Erzurum, Turkey.
J Int Med Res. 2006 Mar-Apr;34(2):193-9. doi: 10.1177/147323000603400209.
In this study, levels of lipid peroxidation and antioxidant enzyme activities were investigated in the erythrocytes of patients with oesophageal and gastric cancers. Erythrocytes were obtained from 17 patients with oesophageal cancer, 37 patients with gastric cancer and 20 healthy controls. Levels of malondialdehyde (MDA), a lipid peroxidation marker, and activities of copper- and zinc-containing superoxide dismutase (CuZn-SOD), catalase (CAT) and glutathione peroxidase (GPx) were determined using spectrophotometric methods. MDA levels and CuZn-SOD activity were significantly higher and GPx and CAT activities significantly lower in patients with oesophageal and gastric cancer than in controls. There were no statistically significant differences in the parameters measured in relation to disease stage in either patient group. These results indicate significant changes in the antioxidant defence system in patients with oesophageal and gastric cancer. It is postulated that this may lead to enhanced action of oxygen radicals, resulting in lipid peroxidation.
在本研究中，对食管癌和胃癌患者红细胞中的脂质过氧化水平和抗氧化酶活性进行了调查。从17例食管癌患者、37例胃癌患者和20名健康对照者获取红细胞。使用分光光度法测定脂质过氧化标志物丙二醛（MDA）的水平以及含铜和锌的超氧化物歧化酶（CuZn-SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）的活性。食管癌和胃癌患者的MDA水平及CuZn-SOD活性显著高于对照组，而GPx和CAT活性显著低于对照组。在任一患者组中，所测参数与疾病分期均无统计学显著差异。这些结果表明食管癌和胃癌患者的抗氧化防御系统发生了显著变化。据推测，这可能导致氧自由基作用增强，从而引发脂质过氧化。
