[Bone and bone related biochemical examinations. Bone and collagen related metabolites. Biomarkers for cartilage matrix turnover and destruction in joint diseases].

Now, it is becoming known that the mechanisms of cartilage matrix destruction such as roles of degradative enzymes and cytokines. It is important to develop the reliable biomarkers to detect the early stage of cartilage destruction. The biomarker could be useful tool not only to understand the progression of joint destruction in osteoarthritis and rheumatoid arthritis but also to develop new treatment.