Musculoskeletal Research Group, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK.
Vet J. 2010 Jul;185(1):43-9. doi: 10.1016/j.tvjl.2010.04.012. Epub 2010 May 21.
Osteoarthritis (OA) results in the destruction and breakdown of articular cartilage matrix. Breakdown of the cartilage proteoglycan component results in the generation of constituent fragments that can be detected in the blood, synovial fluid or urine. Non-collagenous, non-proteoglycan components of cartilage can also be detected following their release as a result of turnover and disease. OA also alters the circulating profile of metabolites in the body. Metabolomic strategies have been used to distinguish populations with OA from normal populations by the creation of a metabolomic 'fingerprint' attributable to the disease. This paper is the second part of a two-part review and describes some of the techniques used to measure the concentrations of some of these 'non-collagenous' biomarkers, and how the application of these measurements assists the study of joint disease. Collagen-based biomarkers were discussed in part one.
骨关节炎（OA）导致关节软骨基质的破坏和分解。软骨蛋白聚糖成分的分解会产生可在血液、滑液或尿液中检测到的组成片段。软骨的非胶原、非蛋白聚糖成分也可以在其由于代谢和疾病而释放后被检测到。OA 还会改变体内代谢物的循环特征。代谢组学策略已被用于通过创建归因于疾病的代谢组“指纹”来区分 OA 人群和正常人群。本文是两部分综述的第二部分，介绍了一些用于测量这些“非胶原”生物标志物浓度的技术，以及这些测量的应用如何有助于关节疾病的研究。第一部分讨论了基于胶原的生物标志物。
