Kagu M B, Ahmed S G, Bukar A A
Department of Haematology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
Afr J Med Med Sci. 2005 Dec;34(4):399-402.
Pre-treatment tumour lysis syndrome (pre-TTLS) is not an unusual clinical entity in high-grade lymphomas and lymphoblastic leukaemias. The overall incidence and frequency is unknown and to the best of our knowledge none has been published in Nigeria involving adult females with advanced stage Burkitt's lymphoma (ASBL). Three of the reported cases had pre-TTLS complicated by acute renal failure (ARF). The first two cases had a complete reversal of the ARF with aggressive supportive management and slow introduction of cytotoxic chemotherapy whereas the third case died of ARF due to delay in commencement of aggressive supportive management, chemotherapy and haemodialysis due to financial constraint. This paper stresses the importance of aggressive supportive management and slow introduction of cytotoxic chemotherapy in patients with a stage C and/or stage D Burkitt's lymphoma presenting with pre-TTLS.
治疗前肿瘤溶解综合征（pre-TTLS）在高级别淋巴瘤和淋巴细胞白血病中并非罕见的临床实体。其总体发病率和发生频率尚不清楚，据我们所知，尼日利亚尚未发表过涉及成年女性晚期伯基特淋巴瘤（ASBL）的相关报道。已报告的病例中有3例出现了合并急性肾衰竭（ARF）的pre-TTLS。前两例通过积极的支持治疗和缓慢引入细胞毒性化疗，ARF完全逆转，而第三例因经济限制导致积极支持治疗、化疗和血液透析开始延迟，最终死于ARF。本文强调了对于出现pre-TTLS的C期和/或D期伯基特淋巴瘤患者，积极支持治疗和缓慢引入细胞毒性化疗的重要性。
