新型戊二酰亚胺抗生素S632A3的分离、结构测定及生物活性

Isolation, structure determination and biological activity of a new glutarimide antibiotic, S632A3.

作者信息

Cheng Chun-Lei, Liu Qiong-Yan, Chen Li-Hui, Jin Wen-Zao, Si Shu-Yi, Li Dian-Dong

机构信息

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.

出版信息

J Asian Nat Prod Res. 2006 Jan-Mar;8(1-2):55-60. doi: 10.1080/10286020500382884.

DOI:10.1080/10286020500382884

PMID:16753783

Abstract

A new antibiotic, S632A3, was isolated from a cultured broth of Streptomyces hygroscopicus S632. It was purified by column chromatography on silica gel, Sephadex LH-20 and HPLC. Structural studies by analysis of 1H NMR and 13C NMR, MS, UV and IR spectra in comparison with those of S632A2 clarified that S632A3 is an isomer of 9-methylstreptimidone. In addition, this antibiotic showed potent biological activity including differentiation induction effects on HL-60 cell and antitumour activity in vivo.

摘要

一种新的抗生素S632A3，是从吸水链霉菌S632的培养液中分离得到的。通过硅胶柱色谱、葡聚糖凝胶LH - 20柱色谱和高效液相色谱对其进行了纯化。通过对1H NMR、13C NMR、质谱、紫外光谱和红外光谱的分析，并与S632A2的光谱进行比较，结构研究表明S632A3是9 - 甲基链霉咪唑酮的异构体。此外，这种抗生素表现出强大的生物活性，包括对HL - 60细胞的分化诱导作用和体内抗肿瘤活性。