两株链霉菌 HS-NF-780 产生的新型戊二酰亚胺类抗生素。

Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780.

机构信息

Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin, China.

College of Biochemical Engineering, Anhui Polytechnic University, Wuhu, China.

出版信息

J Antibiot (Tokyo). 2019 Apr;72(4):241-245. doi: 10.1038/s41429-019-0143-6. Epub 2019 Jan 29.

DOI:10.1038/s41429-019-0143-6

PMID:30696946

Abstract

Two new glutarimide antibiotics, 9-methylstreptimidone 2-α-D-glucopyranoside (1), and hydroxyiso-9-methylstreptimidone (2), along with a known compound, 9-methylstreptimidone (3), have been isolated from the broth of Streptomyces sp. HS-NF-780. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. By modified Mosher's method and acid hydrolysis, the absolute configurations of compounds 1 and 2 were established. Compounds 1 and 2 exhibited moderate cytotoxic activity.

摘要

从链霉菌 HS-NF-780 的发酵液中分离得到两个新的戊二酰亚胺类抗生素，9-甲基链酶菌素 2-α-D-吡喃葡萄糖苷（1）和羟基异-9-甲基链酶菌素（2），以及一个已知化合物 9-甲基链酶菌素（3）。根据光谱分析，包括 1D 和 2D NMR 技术以及 ESI-MS，并与文献数据进行比较，确定了它们的结构。通过改进的 Mosher 法和酸水解，确定了化合物 1 和 2 的绝对构型。化合物 1 和 2 表现出中等的细胞毒性活性。