a State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , 800 Dongchuan Road, Shanghai 200240 , P.R. China.
Nat Prod Res. 2014;28(19):1602-6. doi: 10.1080/14786419.2014.928877. Epub 2014 Jun 20.
Four glutarimide-derived compounds including a new 3-[2-[2-hydroxy-3-methylphenyl-5-(hydroxymethyl)]-2-oxoethyl] glutarimide (1) and three known 3-[2-(2-hyroxy-3,5- dimethylphenyl)-2-oxoethyl] glutarimide (2, actiphenol), 3-hydroxy-3-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl] glutarimide (3) and 3-[2-[2-hydroxy-3-(hydroxymethyl)-5-methylphenyl]-2-oxoethyl] glutarimide (4), along with a known indole alkaloid 3-(hydroxyacetyl) indole (5), were isolated from ethyl acetate extract of the fermentation broth of the marine sponge-derived Streptomyces anulatus S71. Their structures were deduced by extensive studies of NMR and mass spectra.
从海洋海绵来源的链霉菌 S71 的发酵液的乙酸乙酯提取物中分离得到了四种戊二酰亚胺类化合物，包括一种新的 3-[2-[2-羟基-3-甲基苯基-5-(羟甲基)]-2-氧代乙基]戊二酰亚胺（1）和三种已知的 3-[2-(2-羟基-3,5-二甲基苯基）-2-氧代乙基]戊二酰亚胺（2、actiphenol）、3-羟基-3-[2-(2-羟基-3,5-二甲基苯基）-2-氧代乙基]戊二酰亚胺（3）和 3-[2-[2-羟基-3-（羟甲基）-5-甲基苯基]-2-氧代乙基]戊二酰亚胺（4），以及一种已知的吲哚生物碱 3-（羟乙酰基）吲哚（5）。通过对 NMR 和质谱的广泛研究推导出了它们的结构。
