Linnet K M, Wisborg K, Agerbo E, Secher N J, Thomsen P H, Henriksen T B
Perinatal Epidemiology Research Unit, Department of Obstetrics and Pediatrics, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark.
Arch Dis Child. 2006 Aug;91(8):655-60. doi: 10.1136/adc.2005.088872. Epub 2006 Jun 5.
To study the association between gestational age and birth weight and the risk of clinically verified hyperkinetic disorder.
Nested case-control study of 834 cases and 20 100 controls with incidence density sampling.
Compared with children born at term, children born with gestational ages of 34-36 completed weeks had a 70% increased risk of hyperkinetic disorder (rate ratio (RR) 1.7, 95% confidence interval (CI) 1.2 to 2.5). Children with gestational ages below 34 completed weeks had an almost threefold increased risk (RR 2.7, 95% CI 1.8 to 4.1). Children born at term with birth weights of 1500-2499 g had a 90% increased risk of hyperkinetic disorder (RR 1.9, 95% CI 1.2 to 2.9), and children with birth weights of 2500-2999 g had a 50% increased risk (RR 1.5, 95% CI 1.2 to 1.8) compared with children born at term with birth weights above 2999 g. The results were adjusted for socioeconomic status of the parents, family history of psychiatric disorders, conduct disorders, comorbidity, and maternal smoking during pregnancy. Results related to birth weight were unchanged after adjusting for differences in gestational age.
Children born preterm, also close to term, and children born at term with low birth weights (1500-2499 g) have an increased risk of clinically verified hyperkinetic disorder. These findings have important public health perspectives because the majority of preterm babies are born close to term.
研究胎龄和出生体重与经临床证实的多动障碍风险之间的关联。
采用发病密度抽样对834例病例和20100例对照进行巢式病例对照研究。
与足月出生的儿童相比，孕34 - 36足周出生的儿童患多动障碍的风险增加70%（率比（RR）1.7，95%置信区间（CI）1.2至2.5）。孕34足周以下出生的儿童患多动障碍的风险增加近两倍（RR 2.7，95% CI 1.8至4.1）。与出生体重超过2999g的足月出生儿童相比，出生体重为1500 - 2499g的足月出生儿童患多动障碍的风险增加90%（RR 1.9，95% CI 1.2至2.9），出生体重为2500 - 2999g的儿童患多动障碍的风险增加50%（RR 1.5，95% CI 1.2至1.8）。对父母的社会经济状况、精神障碍家族史、品行障碍、合并症以及孕期母亲吸烟情况进行了校正。在校正胎龄差异后，与出生体重相关的结果未发生变化。
早产（包括接近足月）的儿童以及足月出生但低体重（1500 - 2499g）的儿童经临床证实患多动障碍的风险增加。这些发现具有重要的公共卫生意义，因为大多数早产婴儿是接近足月出生的。
