Division of Neonatology, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Pediatrics. 2011 Nov;128(5):e1187-94. doi: 10.1542/peds.2010-3781. Epub 2011 Oct 10.
To describe growth in moderately preterm-born children, determine the prevalence of growth restraint at the age of 4, and identify predictors of growth restraint. We hypothesized that growth in moderately preterm-born children differs from growth in term-born children and that growth restraint is more prevalent in those born prematurely.
This was a community-based cohort study of 1123 children born moderately prematurely (gestational age [GA]: 32-35 6/7 weeks) between January 2002 and June 2003.
On average, we found that moderately preterm-born children were shorter and weighed less at each assessment during the first 4 years of life than their term-born counterparts. Thirty-two boys (5.6%) and 18 girls (3.8%) were growth-restricted in height, and 21 boys (3.4%) and 27 girls (5.8%) were growth-restricted in weight. Their growth in head circumference was normal compared with term-born children. In addition, growth restraint was associated with being small for GA at birth (odds ratio [OR] for height: 7.7 [95% confidence interval (CI): 2.9-20.4]; OR for weight: 9.5 [95% CI: 3.9-23.1]) and maternal height below -1 SD (OR for height: 4.9 [95% CI: 2.6-10.2]; OR for weight: 2.6 [95% CI: 1.3-5.2]). Poor head-circumference growth was associated with a low level of maternal education (OR: 5.3 [95% CI: 1.4-20.8]).
Growth in moderately preterm-born children significantly differs from that of term-born children. Predictors at birth are being small for GA, maternal height below -1 SD, and a low level of maternal education. The fact that growth in moderately preterm-born children may lag warrants close monitoring during routine practice. Additional research on prevention of growth restraint is needed.
描述中度早产儿的生长情况，确定 4 岁时生长受限的发生率，并确定生长受限的预测因素。我们假设，中度早产儿的生长情况与足月出生的儿童不同，并且早产儿中生长受限更为普遍。
这是一项基于社区的队列研究，纳入了 1123 名 2002 年 1 月至 2003 年 6 月期间中度早产（胎龄[GA]：32-35 6/7 周）的儿童。
平均而言，我们发现中度早产儿在生命的前 4 年的每次评估中都比足月出生的儿童矮且体重轻。32 名男孩（5.6%）和 18 名女孩（3.8%）身高受限，21 名男孩（3.4%）和 27 名女孩（5.8%）体重受限。与足月出生的儿童相比，他们的头围生长正常。此外，生长受限与出生时 GA 较小（身高的比值比[OR]：7.7[95%置信区间（CI）：2.9-20.4]；体重的 OR：9.5[95% CI：3.9-23.1]）和母亲身高低于-1 标准差（身高的 OR：4.9[95% CI：2.6-10.2]；体重的 OR：2.6[95% CI：1.3-5.2]）相关。头围生长不良与母亲教育水平较低（OR：5.3[95% CI：1.4-20.8]）有关。
中度早产儿的生长情况与足月出生的儿童明显不同。出生时的预测因素是 GA 较小、母亲身高低于-1 标准差和母亲教育水平较低。事实上，中度早产儿的生长可能会滞后，这需要在常规实践中密切监测。需要进一步研究预防生长受限的方法。
