Wachsman M, Aurelian L, Burnett J W
Department of Pharmacology and Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore 21201.
Toxicon. 1991;29(3):386-90. doi: 10.1016/0041-0101(91)90294-2.
Large intradermal injections of crude sea nettle (Chrysaora quinquecirrha) venom in normal saline produced immunosuppression in a healthy human adult male. This response persisted several days and was homologous against that coelenterate antigen but also heterologous against antigens contained within vaccinia and herpes simplex viruses and tetanus bacillus. This down-regulation of immunity was probably mediated by cells with functional properties of suppressor cells and could be reversed by indomethacin suggesting a role for prostaglandins. This result suggests the possibility that naturally occurring environmental agents, other than sunlight, may influence the human immune response.
在生理盐水中向一名健康成年男性大剂量皮内注射粗制海荨麻（金黄海蜇）毒液可导致免疫抑制。这种反应持续了数天，对该腔肠动物抗原具有同源性，但对牛痘病毒、单纯疱疹病毒和破伤风杆菌所含抗原也具有异源性。这种免疫下调可能是由具有抑制细胞功能特性的细胞介导的，吲哚美辛可使其逆转，提示前列腺素发挥了作用。这一结果表明，除阳光外，自然存在的环境因素可能会影响人类免疫反应。
