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海漆叶中的五环三萜类化合物。

Pentacyclic triterpenoids from leaves of Excoecaria agallocha.

作者信息

Zou Jian-Hua, Dai Jungui, Chen Xiaoguang, Yuan Jing-Quan

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Beijing 100050, PR China.

出版信息

Chem Pharm Bull (Tokyo). 2006 Jun;54(6):920-1. doi: 10.1248/cpb.54.920.

DOI:10.1248/cpb.54.920
PMID:16755073
Abstract

A new oleanane-type triterpenoid (1) and five known pentacyclic triterpenoids (2-6) were isolated from the leaves of Excoecaria agallocha. Their structures were elucidated by spectroscopic analyses. The new compound was characterized as 3beta-[(2E,4E)-5-oxo-decadienoyloxy]-olean-12-ene (1). Compounds 1-6 were found inactive in vitro against several human cancer cell lines.

摘要

从海漆的叶子中分离出一种新的齐墩果烷型三萜(1)和五种已知的五环三萜(2 - 6)。通过光谱分析阐明了它们的结构。新化合物被鉴定为3β - [(2E,4E)-5-氧代-癸二烯酰氧基]-齐墩果-12-烯(1)。发现化合物1 - 6在体外对几种人类癌细胞系无活性。

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