Blume 中的生物活性三萜
Bioactive triterpenoids from Blume.
机构信息
Department of Traditional Medicine, Yunnan University of Chinese Medicine , Kunming , China.
出版信息
Nat Prod Res. 2020 Oct;34(19):2816-2821. doi: 10.1080/14786419.2019.1596092. Epub 2019 Apr 10.
A new triterpene, javablumine A () along with six known ones were isolated from the aerial parts of Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (), ursolic acid (), pomolic acid (), oleanic acid (), 2α-hydroxy-oleanolic acid (), α-amyrin (), and lupeol palmitate (), respectively. Compounds and exhibited inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophage cell lines with IC values of 17.4 and 26.2 μM, respectively.
从 Blume 的地上部分分离得到一种新的三萜类化合物 javablumine A ()，以及六种已知化合物。它们分别被鉴定为 3β,23-二羟基-11α,12α-环氧乌苏-20(30)-烯-28,13β-内酯 ()、乌苏酸 ()、齐墩果酸 ()、熊果酸 ()、2α-羟基乌苏酸 ()、α-香树脂醇 () 和棕榈酸羽扇豆醇酯 ()。化合物 和 对脂多糖 (LPS) 激活的 RAW264.7 巨噬细胞系中的一氧化氮 (NO) 产生具有抑制作用，IC 值分别为 17.4 和 26.2 μM。
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