Cascalho Marilia, Platt Jeffrey L
Transplantation Biology Program and the Departments Surgery, Immunology and Pediatrics, Mayo Clinic College of Medicine, Rochester, Minnesota.
Transfus Med Hemother. 2006;33(1):45-49. doi: 10.1159/000090196.
T cells that provide vital protection against tumors, viruses and intracellular bacteria are thought to develop independently of B cells. However, recent discoveries suggest that development of T cells depends on B cells. One way B cells promote T cell development is by providing diverse peptides that may promote positive selection of thymocytes. Diverse peptides and B cells help in diversification of the T cell receptor repertoire and may decrease cross-reactivity in the mature T cell compartment. These new insights may provide the basis for the design of novel therapeutics.
人们认为，对肿瘤、病毒和细胞内细菌提供重要保护的T细胞是独立于B细胞发育的。然而，最近的发现表明，T细胞的发育依赖于B细胞。B细胞促进T细胞发育的一种方式是提供多种可能促进胸腺细胞阳性选择的肽。多种肽和B细胞有助于T细胞受体库的多样化，并可能降低成熟T细胞区室中的交叉反应性。这些新见解可能为新型疗法的设计提供基础。
