Richardson E D, Malloy P F, Longabaugh R, Williams J, Noel N, Beattie M C
Butler Hospital, Providence, RI 02906.
Addict Behav. 1991;16(1-2):51-5. doi: 10.1016/0306-4603(91)90039-k.
The relationship between residual neuropsychologic dysfunction in alcoholics and subtle changes in liver function during acute phases of treatment was examined. Noncirrhotic alcoholics who exhibited extreme elevations in the liver enzyme gamma-glutamyl transferase (GGT) were found to have greater impairments in tasks of visuoperceptual and conceptual abilities when compared to alcoholics with normal or only mild elevations in GGT. The relationship between acute liver dysfunction and residual neuropsychologic impairment appeared to be independent of age and patterns of drinking. The implications of these findings in relation to treatment planning and prognosis of alcoholics are discussed.
研究了酒精中毒者残留神经心理功能障碍与治疗急性期肝功能细微变化之间的关系。与谷氨酰转移酶（GGT）正常或仅轻度升高的酗酒者相比，发现肝脏酶γ-谷氨酰转移酶（GGT）极度升高的非肝硬化酗酒者在视觉感知和概念能力任务上有更大的损伤。急性肝功能障碍与残留神经心理损伤之间的关系似乎与年龄和饮酒模式无关。讨论了这些发现对酗酒者治疗计划和预后的影响。
