Malloy P, Noel N, Longabaugh R, Beattie M
Butler Hospital, Providence, RI 02809.
Addict Behav. 1990;15(5):431-8. doi: 10.1016/0306-4603(90)90029-w.
Persons displaying Antisocial Personality Disorder (ASP) may be at risk for neuropsychological impairment due to a number of developmental and later life experiences to which they are prone. Thirty substance abusers meeting research criteria for ASP were compared to a demographically matched non-ASP cohort on neuropsychological test performance. The ASP subjects were found to have a higher prevalence of neuropsychological deficit. The groups were then compared on factors which might lead to brain impairment. Presence of ASP was associated with earlier and heavier past drinking patterns, more negative health and behavioral effects of alcohol abuse, and greater abuse of other drugs in addition to alcohol. The ASP alcoholics also reported a high prevalence of serious head injury (58%), although they did not differ from non-ASP alcoholics in this regard. Implications for the neuropsychology of alcoholism and for treatment are discussed.
患有反社会人格障碍（ASP）的人可能因一系列他们容易经历的发育和后期生活经历而面临神经心理损伤的风险。将30名符合ASP研究标准的药物滥用者与在人口统计学上匹配的非ASP队列在神经心理测试表现上进行比较。发现ASP受试者神经心理缺陷的患病率更高。然后在可能导致脑损伤的因素方面对两组进行比较。ASP的存在与过去更早、更严重的饮酒模式、酒精滥用对健康和行为的更多负面影响以及除酒精外对其他药物的更多滥用有关。ASP酗酒者还报告严重头部受伤的患病率很高（58%），尽管他们在这方面与非ASP酗酒者没有差异。本文讨论了对酒精中毒神经心理学和治疗的影响。
