慢性酒精中毒男性的分级神经心理损伤与γ-谷氨酰转移酶升高

Graded neuropsychological impairment and elevated gamma-glutamyl transferase in chronic alcoholic men.

作者信息

Irwin M, Smith T L, Butters N, Brown S, Baird S, Grant I, Schuckit M A

机构信息

Clinical Center for Research on Alcoholism, San Diego Veterans Administration Medical Center, La Jolla, CA 92161.

出版信息

Alcohol Clin Exp Res. 1989 Feb;13(1):99-103. doi: 10.1111/j.1530-0277.1989.tb00292.x.

DOI:10.1111/j.1530-0277.1989.tb00292.x

PMID:2564260

Abstract

This study hypothesizes that distinct biochemical and metabolic disturbances associated with liver injury may be related to specific cognitive changes in alcoholics. In 132 alcoholic men admitted to an alcohol treatment program, increases in gamma-glutamyl transferase (GGT) values were correlated with impairment in several measures of visuoperceptual and visuoconceptual functioning. The association between plasma levels of GGT and neuropsychological performance was independent of the relative contribution of other laboratory measures of liver injury and of alcohol consumption histories. These observations support the hypothesis that elevated levels of GGT are distinctly associated with neuropsychological deficits and suggest that possible mechanisms beyond severe hepatic dysfunction and alcohol consumption underlie cognitive deficits in alcoholics.

摘要

本研究假设，与肝损伤相关的独特生化和代谢紊乱可能与酗酒者特定的认知变化有关。在132名进入酒精治疗项目的男性酗酒者中，γ-谷氨酰转移酶（GGT）值的升高与视觉感知和视觉概念功能的多项指标受损相关。GGT血浆水平与神经心理表现之间的关联独立于肝损伤其他实验室指标以及饮酒史的相对影响。这些观察结果支持了以下假设，即GGT水平升高与神经心理缺陷明显相关，并表明除了严重肝功能障碍和饮酒之外，可能存在其他机制导致酗酒者出现认知缺陷。