Murphy James G, MacKillop James
Department of Psychology, Auburn University, USA.
Exp Clin Psychopharmacol. 2006 May;14(2):219-27. doi: 10.1037/1064-1297.14.2.219.
The construct of relative reinforcing efficacy (RRE) is central to many laboratory and theoretical models of drug abuse, but it has not been widely measured in applied clinical research contexts. The authors used a simulated alcohol purchase task to measure RRE in a sample of 267 college student drinkers. Participants reported their alcohol consumption across a range of prices, and their responses were well-described by a regression equation that has been used to construct demand curves in drug self-administration studies. Several measures of relative reinforcing efficacy were generated, including breakpoint, intensity of demand, elasticity, P-sub(max) (price at which response output is maximized), and O-sub(max) (maximum alcohol expenditures). Demand for alcohol was inelastic across the initial range of prices but became elastic as price increased. Students who reported recent heavy drinking reported significantly greater intensity of demand, O-sub(max), and breakpoint. These results provide initial support for the validity of the RRE indices generated with the alcohol purchase task. These results also provide empirical support for programs that attempt to reduce alcohol abuse by eliminating low-cost access to alcohol.
相对强化效能(RRE)这一概念在许多药物滥用的实验室和理论模型中处于核心地位,但在应用临床研究环境中尚未得到广泛测量。作者使用一项模拟酒精购买任务,对267名大学生饮酒者样本进行了相对强化效能的测量。参与者报告了他们在一系列价格下的酒精消费量,其反应通过一个回归方程得到了很好的描述,该方程已被用于构建药物自我给药研究中的需求曲线。生成了几种相对强化效能的测量指标,包括断点、需求强度、弹性、P-max(反应输出最大化时的价格)和O-max(最大酒精支出)。在初始价格范围内,对酒精的需求缺乏弹性,但随着价格上涨变得具有弹性。报告近期大量饮酒的学生报告的需求强度、O-max和断点显著更高。这些结果为通过酒精购买任务生成的相对强化效能指数的有效性提供了初步支持。这些结果也为试图通过消除低成本酒精获取途径来减少酒精滥用的项目提供了实证支持。