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支气管内肺诺卡菌病

Endobronchial pulmonary nocardiosis.

作者信息

Kumar Neena, Ayinla Raji

机构信息

PGY-2, Northern General Hospital, New York, NY 10801, USA.

出版信息

Mt Sinai J Med. 2006 May;73(3):617-9.

Abstract

In recent years, the reported incidence of nocardiosis, a localized or disseminated infection caused by Nocardia, has been increasing. This increase can be attributed to the improvements in diagnostic capabilities and the higher clinical index of suspicion, as well as the increased prevalence of immunosuppressed patients. We report a case of pulmonary nocardiosis in a healthy young female who presented with cough and hemoptysis, which persisted even after empiric treatment for pulmonary tuberculosis. CT scan of her chest showed infiltrates in the right upper, middle and lower lobes with pleural effusion. Bronchoscopy revealed a friable endobronchial mass. Special stains confirmed the diagnosis of nocardiosis. The patient's symptoms and clinical findings improved with trimethoprim-sulfamethoxazole. To the best of our knowledge, this is the fourth case of this illness presenting as endobronchial mass reported in the literature. Pulmonary nocardiosis should be considered in the differential diagnosis of hemoptysis, even in immunocompetent patients.

摘要

近年来,由诺卡菌引起的局部或播散性感染——诺卡菌病的报告发病率一直在上升。这种上升可归因于诊断能力的提高、更高的临床怀疑指数,以及免疫抑制患者患病率的增加。我们报告一例健康年轻女性的肺诺卡菌病病例,该患者表现为咳嗽和咯血,即使在接受经验性抗肺结核治疗后仍持续存在。她的胸部CT扫描显示右上、中、下叶有浸润影并伴有胸腔积液。支气管镜检查发现一个易碎的支气管内肿物。特殊染色确诊为诺卡菌病。患者的症状和临床体征在使用甲氧苄啶-磺胺甲恶唑治疗后有所改善。据我们所知,这是文献中报道的第四例以支气管内肿物形式出现的该病病例。即使在免疫功能正常的患者中,咯血的鉴别诊断也应考虑肺诺卡菌病。

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