Schulz S, Yuen P S, Garbers D L
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235-9041.
Trends Pharmacol Sci. 1991 Mar;12(3):116-20. doi: 10.1016/0165-6147(91)90519-x.
The guanylyl cyclase receptor family contains members that exist in both the particulate and soluble fractions of cell homogenates. Soluble forms of the enzyme recognize EDRF (nitric oxide) or similar molecules, while diversity within the extracellular domain of the plasma membrane forms has resulted in a series of guanylyl cyclases that are specifically activated by different ligands. David Garbers and colleagues describe the recent cloning of some of these molecules.
鸟苷酸环化酶受体家族包含存在于细胞匀浆的颗粒部分和可溶部分中的成员。该酶的可溶形式识别内皮舒张因子（一氧化氮）或类似分子，而质膜形式的细胞外结构域内的多样性导致了一系列由不同配体特异性激活的鸟苷酸环化酶。大卫·加伯斯及其同事描述了其中一些分子的近期克隆情况。
