Dennis Sara J, Thomas Michael A, Williams Daniel B, Robins Jared C
Center for Reproductive Health, University of Cincinnati, Cincinnati, Ohio, USA.
J Assist Reprod Genet. 2006 Apr;23(4):171-5. doi: 10.1007/s10815-006-9027-3. Epub 2006 May 3.
To determine if embryo cleavage state or morphology on day 3 correlates with implantation or live birth rates. A retrospective cohort study of all fresh embryo transfers over 2 years.
Patients were grouped by the average cleavage state and morphology. Cleavage state groups were: <6, > or =6, <8, and > or =8 cells. Morphology groups by average grade were: group 1 (best) = 1, group 2 = >1< or =2, group 3 = >2< or =3, and group 4 (worst) = >3< or =4.
The overall implantation rate for 158 cycles was 28.1% with a live birth rate of 37.3%. Morphologic state was highly predictive of both implantation rate and live birth rate. Implantation rates by group were 54.8% (group 1), 30.4% (group 2), 23.8% (group 3), and 11.1% (group 4). Likewise, live birth rates among groups were 61.5, 39, 20, and 21%, respectively. Cleavage state was not predictive of outcome.
Embryo grade is highly predictive of implantation and live birth rate and can be used to determine the number of embryos to transfer. Cleavage state is not predictive of outcome.
确定第3天胚胎的分裂状态或形态是否与着床率或活产率相关。对2年多来所有新鲜胚胎移植进行的一项回顾性队列研究。
根据平均分裂状态和形态对患者进行分组。分裂状态组为：<6细胞、≥6细胞、<8细胞和≥8细胞。形态学组按平均等级分为：第1组（最佳）=1级，第2组=>1且≤2级，第3组=>2且≤3级，第4组（最差）=>3且≤4级。
158个周期的总体着床率为28.1%，活产率为37.3%。形态学状态对着床率和活产率均具有高度预测性。各组的着床率分别为54.8%（第1组）、30.4%（第2组）、23.8%（第3组）和11.1%（第4组）。同样，各组的活产率分别为61.5%、39%、20%和21%。分裂状态不能预测结局。
胚胎等级对着床率和活产率具有高度预测性，可用于确定移植胚胎的数量。分裂状态不能预测结局。
