IVI Valencia, Valencia, Spain.
Institut Universitari Dexeus, Barcelona, Spain.
Fertil Steril. 2014 Apr;101(4):981-7. doi: 10.1016/j.fertnstert.2013.12.043. Epub 2014 Feb 4.
To investigate the impact of early cleavage (EC) on embryo quality, implantation, and live-birth rates.
Prospective cross-sectional study.
Multicenter study.
PATIENT(S): Seven hundred embryo transfers and 1,028 early-stage human embryos.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Implantation according to the presence of EC and embryo quality.
RESULT(S): The presence of EC is associated with embryo quality, especially in cycles with autologous oocytes. However, the use of EC as an additional criterion for selecting an embryo for transfer does not appear to significantly improve likelihood of implantation. Furthermore, embryos that presented EC had live-birth rates per implanted embryo similar to those that did not show any sign of cleavage.
CONCLUSION(S): At least for conventional embryo culture and morphologic evaluations, the additional evaluation of EC in embryos may not be valuable to improve embryo implantation.
探讨早期卵裂（EC）对胚胎质量、着床和活产率的影响。
前瞻性横断面研究。
多中心研究。
700 次胚胎移植和 1028 个早期人类胚胎。
无。
根据 EC 的存在和胚胎质量评估着床情况。
EC 的存在与胚胎质量相关，尤其是在自体卵母细胞周期中。然而，将 EC 用作选择胚胎进行移植的额外标准似乎并不能显著提高着床的可能性。此外，表现出 EC 的胚胎的活产率与没有任何卵裂迹象的胚胎相似。
至少对于常规胚胎培养和形态学评估而言，对胚胎中 EC 的额外评估可能无法提高胚胎着床率。
