促卵泡生成素受体基因多态性在接受体外受精/卵胞浆内单精子注射-胚胎移植（IVF/ICSI-ET）治疗的患者中，对卵巢刺激的不同反应起作用。
FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs.
作者信息
Loutradis Dimitris, Patsoula Eleni, Minas Vassilis, Koussidis Giorgos A, Antsaklis Aristeidis, Michalas Stylianos, Makrigiannakis Antonis
机构信息
Division of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynaecology, Athens University Medical School, Athens, Greece.
出版信息
J Assist Reprod Genet. 2006 Apr;23(4):177-84. doi: 10.1007/s10815-005-9015-z. Epub 2006 May 19.
Abstract
PURPOSE
To examine the frequency distribution of the Ser680Asn polymorphism of the follicle-stimulating hormone receptor (FSHR) gene in ovarian dysfunction (OD) infertile women, "poor responders" (PR) and "good responders" (GR).
METHODS
The hormonal profiles and treatment of all patients were analyzed and FSHR polymorphism was examined by PCR and RFLP. Women from all groups were classified as Asn/Asn, Asn/Ser, and Ser/Ser genotypes.
RESULTS
The frequency distribution of Ser/Ser, Asn/Ser and Asn/Asn variants in OD patients was 45.5, 22.7, and 31.8%, respectively. Day 3 FSH levels in OD and GR patients were higher in Ser/Ser and Asn/Asn subgroups. Asn/Ser carriers from OD and GR groups provided more follicles and oocytes compared to other allelic variants.
CONCLUSIONS
GR patients carry more often the Asn/Ser genotype. The latter is correlated with more follicles and oocytes in both OD and GR patients. The Ser/Ser variant might be related to higher serum FSH levels, while the Asn/Ser with lower.
摘要
目的
研究卵泡刺激素受体（FSHR）基因Ser680Asn多态性在卵巢功能障碍（OD）不孕女性、“低反应者”（PR）和“高反应者”（GR）中的频率分布。
方法
分析所有患者的激素水平及治疗情况，并通过聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）检测FSHR基因多态性。将所有组别的女性分为Asn/Asn、Asn/Ser和Ser/Ser基因型。
结果
OD患者中Ser/Ser、Asn/Ser和Asn/Asn变异体的频率分布分别为45.5%、22.7%和31.8%。OD和GR患者中，Ser/Ser和Asn/Asn亚组的第3天促卵泡生成素（FSH）水平较高。与其他等位基因变异体相比，OD和GR组的Asn/Ser携带者产生的卵泡和卵母细胞更多。
结论
GR患者更常携带Asn/Ser基因型。在OD和GR患者中，该基因型均与更多的卵泡和卵母细胞相关。Ser/Ser变异体可能与较高的血清FSH水平有关，而Asn/Ser变异体则与较低的血清FSH水平有关。
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