促卵泡激素受体Ser680Asn多态性在促卵泡激素疗效中的作用
Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.
作者信息
de Castro Francisco, Ruiz Rocío, Montoro Luis, Pérez-Hernández Dámaso, Sánchez-Casas Padilla Elisa, Real Luis M, Ruiz Agustín
机构信息
Unidad de Reproducción Humana Asistida, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
出版信息
Fertil Steril. 2003 Sep;80(3):571-6. doi: 10.1016/s0015-0282(03)00795-7.
OBJECTIVE
To evaluate the association between FSH efficacy and FSHR alleles.
DESIGN
Retrospective study.
SETTING
University-based fertility unit and a private center for biomedical research.
PATIENT(S): One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were categorized as poor responders (< or =3 ovarian follicles at the end of the cycle) or normal responders (>3 follicles).
INTERVENTION(S): Daily administration of exogenous FSH.
MAIN OUTCOME MEASURE(S): Number of good or poor responders.
RESULT(S): The allele frequency and genotype distribution of the Ser680Asn marker differed significantly between groups. Cycle cancellations were increased (21%) among women who were homozygous for Ser680 compared with Ser/Asn and Asn/Asn patients, and 36% of poor-responders were homozygous for Ser680.
CONCLUSION(S): The results support a role for FSHR gene in COS outcome. However, the weight of this factor is probably low. The Ser680 allele may act in concert with other environmental and genetic factors that contribute to FSH efficacy.
目的
评估促卵泡激素（FSH）疗效与促卵泡激素受体（FSHR）等位基因之间的关联。
设计
回顾性研究。
地点
大学附属医院生殖科及一家私立生物医学研究中心。
患者
102例接受控制性卵巢刺激（COS）的卵巢功能正常女性。将患者分为低反应者（周期结束时卵巢卵泡数≤3个）或正常反应者（卵泡数>3个）。
干预措施
每日注射外源性FSH。
主要观察指标
高反应者或低反应者的数量。
结果
Ser680Asn标记的等位基因频率和基因型分布在两组间存在显著差异。与Ser/Asn和Asn/Asn患者相比，Ser680纯合子女性的周期取消率增加（21%），36%的低反应者为Ser680纯合子。
结论
结果支持FSHR基因在COS结局中发挥作用。然而，该因素的影响可能较小。Ser680等位基因可能与其他影响FSH疗效的环境和遗传因素共同起作用。
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