Hartikainen P, Soininen H, Reinikainen K J, Sirviö J, Soikkeli R, Riekkinen P J
Department of Neurology, University of Kuopio, Finland.
J Neural Transm Gen Sect. 1991;84(1-2):103-17. doi: 10.1007/BF01249114.
We have investigated neurotransmitter-related markers of the cerebrospinal fluid (CSF) in a carefully screened series of normally aging subjects in standardized conditions in order to find out the influence of age and other confounding factors on CSF measures. The levels of 3-methoxy-4-hydroxyglycol (MHPG) and the activity of acetylcholinesterase (AChE) also increased with age, while homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5 HIAA) and immunoreactivities of somatostatin (SLI), beta-endorphin (BLI) and adrenocorticotropic hormone (ACTH) were unrelated to age. The gender of subjects had no significant effect on the levels of neurotransmitter markers, while seasonal changes, as well as height and weight of the subjects seemed to cause some variations in the levels of HVA, dopamine-beta-hydroxylase (DBH) and ACTH. The study underscores the importance of standardized conditions and matched patient groups in the CSF studies.
我们在标准化条件下，对一系列经过仔细筛选的正常衰老受试者的脑脊液（CSF）中与神经递质相关的标志物进行了研究，以探究年龄及其他混杂因素对脑脊液检测指标的影响。3-甲氧基-4-羟基乙二醇（MHPG）水平和乙酰胆碱酯酶（AChE）活性也随年龄增长而升高，而高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）以及生长抑素（SLI）、β-内啡肽（BLI）和促肾上腺皮质激素（ACTH）的免疫反应性与年龄无关。受试者的性别对神经递质标志物水平无显著影响，而季节变化以及受试者的身高和体重似乎会导致HVA、多巴胺-β-羟化酶（DBH）和ACTH水平出现一些变化。该研究强调了在脑脊液研究中标准化条件和匹配患者组的重要性。
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