Losonczy M F, Mohs R C, Davis K L
Psychiatry Res. 1984 May;12(1):79-87. doi: 10.1016/0165-1781(84)90140-9.
While circadian rhythms of many biological processes have been well characterized in humans, variations throughout the year have been little studied. Lumbar cerebrospinal fluid (CSF) neurotransmitter metabolite levels for homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were determined in patients with schizophrenia and Alzheimer's disease. Samples from both groups taken during October through March had significantly higher levels of HVA and 5-HIAA, but not MHPG, than samples from April through September.
虽然许多生物过程的昼夜节律在人类中已得到充分表征，但全年的变化却鲜有研究。我们测定了精神分裂症和阿尔茨海默病患者脑脊液中高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和3-甲氧基-4-羟基苯乙二醇（MHPG）的神经递质代谢物水平。两组患者在10月至次年3月采集的样本中，HVA和5-HIAA水平显著高于4月至9月采集的样本，但MHPG水平并非如此。
