Krasavtsev E L, Zhavoronok S V, Mitsura V M, Demchilo A P
Zh Mikrobiol Epidemiol Immunobiol. 2006 Mar-Apr(2):57-61.
A total of 176 hospital patients with chronic hepatitis C (CHC), among them 110 males and 66 females, were examined. The spectrum of antibodies to four hepatitis C virus (HCV) proteins (core, NS3, NS4, NS5) and in 142 patients --IgM antibodies to HCV (anti-HCV IgM) were determined. In 92% of the CHC patients antibodies to core, NS3 and NS4 proteins were simultaneously detected. Differences in the detection of antibodies to HCV in males and females were not statistically reliable. In CHC patients aged up to 20 years anti-NS4 and anti-NS5 were less frequently detected. Among males of different age groups reliable differences in the detection rate of anti-NS5 were registered, while among females of different age groups no such differences were observed. With the increase of age these antibodies were detected somewhat more often. In females over 60 years anti-HCV IgM occurred more often than in males of the same age. The levels of alanine aminotransferase (ALT) were higher in persons with the presence of anti-NS5 and anti-HCV IgM than in persons with their absence. In all groups of CHC patients with biochemical activity and liver cirrhosis the detection rate of anti-HCV IgM was significantly higher than in patients with normal ALT activity. The antibody spectrum with the simultaneous absence of HCV IgM and anti-NS5, while found to contain antibodies to other HCV antigens, was registered significantly less frequently in patients with moderate and high CHC activity and the liver cirrhosis induced by HCV infection.
共对176例慢性丙型肝炎（CHC）住院患者进行了检查，其中男性110例，女性66例。测定了针对四种丙型肝炎病毒（HCV）蛋白（核心蛋白、NS3、NS4、NS5）的抗体谱，142例患者还检测了抗HCV IgM抗体。92%的CHC患者同时检测到针对核心蛋白、NS3和NS4蛋白的抗体。男性和女性抗HCV抗体检测结果的差异无统计学意义。20岁及以下的CHC患者中，抗NS4和抗NS5抗体的检出率较低。不同年龄组男性抗NS5抗体检出率存在显著差异，而不同年龄组女性未观察到此类差异。随着年龄增长，这些抗体的检出率略有增加。60岁以上女性抗HCV IgM的出现频率高于同年龄男性。有抗NS5和抗HCV IgM的患者丙氨酸氨基转移酶（ALT）水平高于无这些抗体的患者。在所有具有生化活性和肝硬化的CHC患者组中，抗HCV IgM的检出率显著高于ALT活性正常的患者。在CHC活动度中等和高以及由HCV感染引起肝硬化的患者中，同时缺乏HCV IgM和抗NS5但含有其他HCV抗原抗体的抗体谱出现频率显著较低。
