Jeanningros R, Mazzola P, Azorin J M, Samuelian-Massa C, Tissot R
Unité de Psychiatrie Biologique, C.N.R.S., Faculté de Médecine, Marseille, France.
Biol Psychiatry. 1991 Apr 15;29(8):789-98. doi: 10.1016/0006-3223(91)90198-u.
Binding parameters of (-)-iodopindolol to beta 2-adrenoceptors were determined on intact mononuclear cells in 41 untreated patients with different DSM-III subtypes of depression. Both maximal beta-receptor density (Bmax) and dissociation constant (Kd) were not significantly different between control and all depressed subjects. However, Bmax was significantly decreased in unipolar patients as compared to controls (p less than 0.001) whereas no significant difference was found in bipolar or dysthymic patients. In unipolar patients, a very strong association was found between Bmax values and the severity of the depression as assessed by the Hamilton Depression Rating Scale score (r = -0.75; p less than 0.005). This correlation was also highly significant in the entire depressed population (r = -0.58; p less than 0.0009). These results suggest that the lower number of beta-adrenoceptors in intact leukocyte cells of depressed patients is related to the depression severity.
在41例未经治疗的、患有不同DSM - III抑郁亚型的患者的完整单核细胞上测定了(-)-碘吲哚洛尔与β2 -肾上腺素能受体的结合参数。对照组与所有抑郁症患者之间的最大β受体密度（Bmax）和解离常数（Kd）均无显著差异。然而，与对照组相比，单相抑郁症患者的Bmax显著降低（p < 0.001），而双相抑郁症或心境恶劣障碍患者未发现显著差异。在单相抑郁症患者中，通过汉密尔顿抑郁量表评分评估发现Bmax值与抑郁严重程度之间存在非常强的关联（r = -0.75；p < 0.005）。这种相关性在整个抑郁症患者群体中也非常显著（r = -0.58；p < 0.0009）。这些结果表明，抑郁症患者完整白细胞中β -肾上腺素能受体数量的减少与抑郁严重程度有关。
