抑郁症中[3H]育亨宾与血小板α2 -肾上腺素能受体的结合
[3H]yohimbine binding to platelet alpha 2-adrenoceptors in depression.
作者信息
Katona C L, Theodorou A E, Davies S L, Hale A S, Kerry S M, Horton R W, Kelly J S, Paykel E S
机构信息
Department of Psychiatry, University College and Middlesex Hospital Medical School, London, U.K.
出版信息
J Affect Disord. 1989 Nov-Dec;17(3):219-28. doi: 10.1016/0165-0327(89)90003-7.
[3H]Yohimbine binding to platelet alpha 2-adrenoceptors was studied in depressed patients and healthy volunteers. Where possible platelet binding measurement was repeated in depressed patients following treatment. Bmax of [3H]yohimbine binding did not differ significantly between depressed patients and control subjects and did not change with treatment in depressed patients. KD was significantly lower in female depressed patients, particularly in those who were post-menopausal. Multivariate analysis showed significant effects on KD of depression, season of testing and assay protein concentration.
研究了[³H]育亨宾与抑郁症患者及健康志愿者血小板α₂ - 肾上腺素能受体的结合情况。在可能的情况下，对抑郁症患者治疗后重复进行血小板结合测量。抑郁症患者与对照受试者之间[³H]育亨宾结合的最大结合容量（Bmax）无显著差异，且抑郁症患者治疗后也未改变。女性抑郁症患者的解离常数（KD）显著较低，尤其是绝经后的女性。多变量分析显示，抑郁症、测试季节和测定蛋白浓度对KD有显著影响。
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