Pandey G N, Janicak P G, Davis J M
Department of Psychiatry, College of Medicine, University of Illinois, Chicago.
Psychiatry Res. 1987 Dec;22(4):265-73. doi: 10.1016/0165-1781(87)90105-3.
We studied beta-adrenergic receptor binding, using 125I-cyanopindolol as the ligand, in the leukocyte membranes of depressed patients, schizophrenic patients, and normal control subjects during a drug-free period. We also determined plasma cortisol levels and dexamethasone suppression in these subjects. The maximum number of beta-adrenergic receptor sites (Bmax) was significantly lower in depressed patients than in normal control subjects. Nonsuppressors on the dexamethasone suppression test tended to have a decreased Bmax in comparison to suppressors. There was no significant difference in the Kd between any of the groups. These results indicate that decreased beta-adrenergic receptor responsiveness in the leukocytes of depressed patients is probably due to a decrease in the number of beta-adrenergic receptor sites.
我们在抑郁患者、精神分裂症患者及正常对照者的无药期，以125I-氰吲哚洛尔作为配体，研究了白细胞膜中的β-肾上腺素能受体结合情况。我们还测定了这些受试者的血浆皮质醇水平及地塞米松抑制情况。抑郁患者的β-肾上腺素能受体位点最大数量（Bmax）显著低于正常对照者。与地塞米松抑制试验的抑制者相比，非抑制者的Bmax往往降低。各组之间的解离常数（Kd）无显著差异。这些结果表明，抑郁患者白细胞中β-肾上腺素能受体反应性降低可能是由于β-肾上腺素能受体位点数量减少所致。
