Guo Huai-lan, Hou Xiao-hui, Yang Xue-feng, Xu Jian
Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Wei Sheng Yan Jiu. 2006 Mar;35(2):194-5.
To study the influence of excessive iodine intake on thyroid hormones in cerebrum of filial mice and intervention of selenium.
60 Balb/c mice were divided randomly into 4 groups: control group, iodine group, selenium group and iodine plus selenium group and given tap water, tap water containing iodine 3000 microg/L, tap water containing selenium 200 microg/L and tap water containing iodine plus selenium 200 microg/L respectively as drinking water. At the end of the fourth month, the mice mated. Thyroid hormones and TSH in serum and in cerebrum of filial mice were determined at the postnatal 0, 14th and 28th day.
At the postnatal 14th day, serum TT4 level was lower significantly, and serum TSH was higher in iodine group than those in control group and in the iodine plus selenium group. At the postnatal 0 day and 14th day, thyroid hormone concentrations in the cerebrum of progeny of mice were lower significantly in iodine group than those in control group, selenium group and iodine plus selenium (P < 0.05). No significant difference was observed among the four groups in TT4, TT3 and rT3 concentrations in serum and cerebrum at the postnatal 28th day.
Excessive iodine intake can change thyroid hormone concentrations in the cerebrum of progeny of mice and selenium supplementation exerted favorable effects on it.
研究过量碘摄入对仔鼠大脑甲状腺激素的影响及硒的干预作用。
将60只Balb/c小鼠随机分为4组：对照组、碘组、硒组和碘加硒组，分别给予自来水、含碘3000μg/L的自来水、含硒200μg/L的自来水和含碘加硒200μg/L的自来水作为饮用水。第4个月末，小鼠进行交配。在仔鼠出生后第0、14和28天测定血清及大脑中的甲状腺激素和促甲状腺激素。
出生后第14天，碘组血清总甲状腺素（TT4）水平显著降低，血清促甲状腺激素（TSH）高于对照组和碘加硒组。出生后第0天和第14天，碘组仔鼠大脑中的甲状腺激素浓度显著低于对照组、硒组和碘加硒组（P<0.05）。出生后第28天，四组血清和大脑中的TT4、三碘甲状腺原氨酸（TT3）和反三碘甲状腺原氨酸（rT3）浓度无显著差异。
过量碘摄入可改变仔鼠大脑中的甲状腺激素浓度，补充硒对此有良好作用。
