Wiesbeck Gerhard A, Dürsteler-MacFarland Kenneth M, Wurst Friedrich Martin, Walter Marc, Petitjean Sylvie, Müller Sandra, Wodarz Norbert, Böning Jobst
Division of Substance Use Disorders, Psychiatric University Hospital Basel, Switzerland.
Addict Biol. 2006 Mar;11(1):72-5. doi: 10.1111/j.1369-1600.2006.00003.x.
This study sought to examine dopamine receptor sensitivity among alcoholics in vivo and to explore whether this sensitivity might be associated with functional variations of dopamine D2 (DRD2) and D3 (DRD3) receptor genes along with a genetic predisposition for alcoholism as reflected by an alcohol-dependent first-degree relative. We analyzed the -141C Ins/Del polymorphism in the promoter region of the DRD2 gene and the Ser9Gly (BalI) polymorphism in exon 1 of the DRD3 gene in 74 alcohol-dependent Caucasian men with or without genetic predisposition for alcoholism. In vivo dopamine receptor sensitivity was assessed by measuring apomorphine-induced growth hormone release. A three-way analysis of variance revealed no significant effects of DRD2, DRD3 genotypes and genetic predisposition on dopamine receptor sensitivity. Given the explorative and preliminary character of this investigation, we cannot provide evidence that in alcohol-dependent Caucasian men a genetic predisposition for alcoholism along with functional variants of the DRD2 and DRD3 genes are associated with differences in dopamine receptor sensitivity.
本研究旨在检测酒精依赖者体内多巴胺受体的敏感性，并探讨这种敏感性是否可能与多巴胺D2（DRD2）和D3（DRD3）受体基因的功能变异有关，以及是否与酒精依赖一级亲属所反映的酒精中毒遗传易感性有关。我们分析了74名有或没有酒精中毒遗传易感性的酒精依赖白种男性中DRD2基因启动子区域的-141C Ins/Del多态性和DRD3基因第1外显子中的Ser9Gly（BalI）多态性。通过测量阿扑吗啡诱导的生长激素释放来评估体内多巴胺受体的敏感性。三因素方差分析显示DRD2、DRD3基因型和遗传易感性对多巴胺受体敏感性无显著影响。鉴于本研究的探索性和初步性，我们无法提供证据表明在酒精依赖的白种男性中，酒精中毒的遗传易感性以及DRD2和DRD3基因的功能变异与多巴胺受体敏感性差异有关。
