多巴胺D2受体基因-141C Ins/Del和TaqI A多态性与酒精中毒的关联研究。
Association study between the -141C Ins/Del and TaqI A polymorphisms of the dopamine D2 receptor gene and alcoholism.
作者信息
Ishiguro H, Arinami T, Saito T, Akazawa S, Enomoto M, Mitushio H, Fujishiro H, Tada K, Akimoto Y, Mifune H, Shioduka S, Hamaguchi H, Toru M, Shibuya H
机构信息
Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, Japan.
出版信息
Alcohol Clin Exp Res. 1998 Jun;22(4):845-8.
Dopamine D2 receptors have been implicated in the biology of alcohol preference. We examined the -141 C Ins/Del polymorphism in the promoter region of the dopamine D2 receptor gene (DRD2) and the DRD2 TaqI A polymorphisms in 209 Japanese alcoholics and 152 age- and sex-matched Japanese controls. The Ins allele was significantly increased in the alcoholics, compared with the controls (p < 0.002, odds ratio = 1.82). The TaqI A1 allele tended to be more frequent in the alcoholics than in the controls (p < 0.04). Linkage disequilibrium between these two polymorphisms was weak (a maximum delta value = 0.13). The -141 C Ins/Del polymorphism may affect the vulnerability for alcoholism presumably through different expression of DRD2 in the Japanese.
多巴胺D2受体与酒精偏好的生物学机制有关。我们检测了209名日本酗酒者和152名年龄及性别匹配的日本对照者的多巴胺D2受体基因（DRD2）启动子区域的-141 C Ins/Del多态性以及DRD2 TaqI A多态性。与对照组相比，酗酒者中Ins等位基因显著增加（p < 0.002，优势比 = 1.82）。TaqI A1等位基因在酗酒者中往往比对照组更常见（p < 0.04）。这两种多态性之间的连锁不平衡较弱（最大δ值 = 0.13）。-141 C Ins/Del多态性可能通过日本人中DRD2的不同表达影响酗酒易感性。
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