Hashimoto Tomoki, Meng Hui, Young William L
Department of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, 1001 Potrero Avenue, Room 3C-38, 94110, USA.
Neurol Res. 2006 Jun;28(4):372-80. doi: 10.1179/016164106X14973.
Abnormal vascular remodeling mediated by inflammatory cells has been identified as a key pathologic component of various vascular diseases, including abdominal aortic aneurysms, brain arteriovenous malformations and atherosclerosis. Based on findings from observational studies that analysed human intracranial aneurysms and experimental studies that utilized animal models, an emerging concept suggests that a key component of the pathophysiology of intracranial aneurysms is sustained abnormal vascular remodeling coupled with inflammation. This concept may provide a new treatment strategy to utilize agents to inhibit inflammation or cytokines produced by inflammatory cells such as matrix metalloproteinases. Such an approach would aim to stabilize these vascular lesions and prevent future expansion or rupture.
由炎症细胞介导的异常血管重塑已被确定为各种血管疾病的关键病理组成部分，包括腹主动脉瘤、脑动静脉畸形和动脉粥样硬化。基于分析人类颅内动脉瘤的观察性研究以及利用动物模型的实验性研究结果，一个新出现的概念表明，颅内动脉瘤病理生理学的一个关键组成部分是持续的异常血管重塑与炎症并存。这一概念可能提供一种新的治疗策略，即使用药物抑制炎症或炎症细胞产生的细胞因子，如基质金属蛋白酶。这种方法旨在稳定这些血管病变，防止未来的扩张或破裂。
