Tseng Hung-Fu, Chang Chen-Kang, Tan Hsiu-Fen, Yang Shu-Er, Chang Hsueh-Wei
Institute of Medical Research, Chang-Jung Christian University, 396, Sec. l, Chang Jung Rd., Kway Jen, Tainan 711, Taiwan.
Vaccine. 2006 Jul 17;24(29-30):5772-7. doi: 10.1016/j.vaccine.2006.04.047. Epub 2006 May 4.
During 2003-2004, approximately 13% of birth in Taiwan was given by foreign-born females. The aims of this study were to compare the seroprevalence of rubella antibodies between Taiwan-born and foreign-born pregnant women and evaluate the effect of rubella vaccination program in Taiwan. We reviewed the rubella antibody test results of 5007 women during routine pregnancy check-ups at Fooyin University Hospital during 1999-2002. In Taiwan-born women, rubella antibody was undetectable in 29.2%, 7.3%, and 8.3% of the cohorts born before 1971, between 1971 and 1976, and after 1976, respectively. In the cohorts born between 1971 and 1976 and after 1976, pregnant women born in China, Vietnam, Indonesia, and Philippines had significant higher chances of being susceptible. Our results suggested that the voluntary adult vaccination program was not as effective as the school or wipe-out programs. Both Taiwanese women born before 1971 and foreign-born women were more likely to be susceptible to rubella. The introduction of 'catch-up' immunization program and enforcement of the checking of immunization record and/or blood test before pregnancy for these women are necessary in preventing CRS.
在2003年至2004年期间，台湾约13%的新生儿由外国出生的女性所生。本研究的目的是比较台湾出生和外国出生的孕妇之间风疹抗体的血清流行率，并评估台湾风疹疫苗接种计划的效果。我们回顾了1999年至2002年期间在辅英科技大学医院进行常规产前检查的5007名女性的风疹抗体检测结果。在台湾出生的女性中，1971年以前、1971年至1976年之间以及1976年以后出生的队列中，风疹抗体检测不到的比例分别为29.2%、7.3%和8.3%。在1971年至1976年之间以及1976年以后出生的队列中，在中国、越南、印度尼西亚和菲律宾出生的孕妇更易感染风疹。我们的结果表明，成人自愿接种计划不如学校接种计划或大规模接种计划有效。1971年以前出生的台湾女性和外国出生的女性都更容易感染风疹。为这些女性引入“补种”免疫计划并在怀孕前强制检查免疫记录和/或进行血液检测对于预防先天性风疹综合征是必要的。
