Wang I-Jen, Huang Li-Ming, Chen Hsiu-Hsi, Hwang Kung-Chang, Chen Chien-Jen
Department of Pediatrics, Taipei Hospital, Department of Health, Taipei, Taiwan.
J Med Virol. 2007 Jan;79(1):97-103. doi: 10.1002/jmv.20764.
Rubella vaccination was implemented nationwide in 1992 in Taiwan. A cross-sectional survey was conducted to determine the age-specific seroprevalence of anti-rubella in female students aged 7-22 years old and women of reproductive age in Taipei County. Seropositivity of anti-rubella antibodies was defined as a serum IgG level > or =10 IU/ml tested by enzyme immunoassay. Information on possible predictors of anti-rubella seronegativity was obtained from structured questionnaire interview. Multivariate-adjusted odds ratios (ORm) with their 95% confidence interval (CI) were derived for each predictor using multiple logistic regression analysis. A total of 826 female students and 318 women were recruited. Anti-rubella seropositive rates were 98.3% (282/287), 99.6% (234/235), 96.8% (179/185), 92.4% (110/119), 81.4% (197/242), and 89.5% (68/76) for the age groups of 7-9, 11-13, 15-17, 19-22, 25-33, and 34-44 years old, respectively. Among female students, negative serology for rubella antibodies was associated significantly with the age group and foreign nationality of mother, showing ORm (95% CI) of 1.2 (1.06-1.27) for each year increase in age, and 20.9 (6.31-68.97), respectively. Among women at the reproductive age, low maternal education level 91.6 (9.12-920.74), unmarried status 21.2 (6.16-72.89), and no rubella vaccination 98.9 (11.64-840.25) were associated significantly with an increased evidence of seronegativity to rubella. The National Rubella Vaccination Program has led to herd immunity of school girls. However, in order to eradicate the Rubella syndrome, greater effort is required to vaccinate foreign brides in Taiwan.
台湾于1992年在全国范围内实施了风疹疫苗接种。开展了一项横断面调查，以确定台北县7至22岁女学生及育龄妇女中抗风疹抗体的年龄特异性血清阳性率。抗风疹抗体血清阳性定义为通过酶免疫测定法检测的血清IgG水平≥10 IU/ml。通过结构化问卷调查获取抗风疹血清阴性可能的预测因素信息。使用多元逻辑回归分析得出每个预测因素的多变量调整比值比（ORm）及其95%置信区间（CI）。共招募了826名女学生和318名妇女。7至9岁、11至13岁、15至17岁、19至22岁、25至33岁和34至44岁年龄组的抗风疹血清阳性率分别为98.3%（282/287）、99.6%（234/235）、96.8%（179/185）、92.4%（110/119）、81.4%（197/242）和89.5%（68/76）。在女学生中，风疹抗体血清学阴性与年龄组及母亲的外国国籍显著相关，年龄每增加一岁的ORm（95%CI）为1.2（1.06 - 1.27），母亲为外国国籍的ORm（95%CI）为20.9（6.31 - 68.97）。在育龄妇女中，母亲教育水平低（91.6，9.12 - 920.74）、未婚状态（21.2，6.16 - 72.89）和未接种风疹疫苗（98.9，11.64 - 840.25）与风疹血清阴性证据增加显著相关。国家风疹疫苗接种计划已导致女学生群体产生群体免疫。然而，为了根除风疹综合征，需要做出更大努力为台湾的外籍新娘接种疫苗。
