Wang I-Jen, Hwang Kung-Chang, Tsai Ya-Huei, Wu Yu-Nian, Chao Shiuch-Jen, Chen Tsui-Er, Huang Li-Min
Department of Pediatrics, Taipei Hospital, Taipei, Taiwan.
Acta Paediatr Taiwan. 2006 Jan-Feb;47(1):14-7.
To better target rubella immunization efforts by determining the age-specific rubella seroprevalence and the related factors for children in Taiwan after the 1986 national vaccine policy. A cross-sectional study was conducted for these girls aged 10 years (1994 cohorts), 13 years (1991 cohorts), 16 years (1988 cohorts), and 19 to approximately 22 years (1982-1985 cohorts), respectively, in 2004 in Taipei county. Participants were given a questionnaire detailing family income, education level, ethnicity of mother, number of siblings, and history of rubella infection. Possible predictors of rubella seropositivity and differences in seroprevalence were calculated by multivariate logistic regression analysis. A total of 826 cases were recruited. The geometric mean titer of rubella IgG antibody was 60.7 +/- 2.1 IU/ml. Rubella seropositive rates were 282/287 (98.3%) in children aged 10 years, 234/235 (99.6%) in aged 13 years, 179/185 (96.8%) in aged 16 years, and 110/119 (92. 4%) in aged 19-22 years. Older age, low maternal education level, and foreign mothers were correlated with seronegativity (p < 0.05). The MMR vaccine program has induced effectively the immunity against rubella. However, to eliminate congenital rubella syndrome, more effort should be taken for the vaccination of susceptible adolescents and young women.
为了通过确定台湾地区1986年国家疫苗政策实施后儿童特定年龄的风疹血清流行率及相关因素，更好地开展风疹免疫工作。2004年在台北县分别对10岁（1994年队列）、13岁（1991年队列）、16岁（1988年队列）以及19至约22岁（1982 - 1985年队列）的女孩进行了一项横断面研究。研究对象填写了一份问卷，详细内容包括家庭收入、教育水平、母亲的种族、兄弟姐妹数量以及风疹感染史。通过多因素逻辑回归分析计算风疹血清阳性的可能预测因素以及血清流行率的差异。共招募了826例研究对象。风疹IgG抗体几何平均滴度为60.7±2.1 IU/ml。10岁儿童风疹血清阳性率为282/287（98.3%），13岁为234/235（99.6%），16岁为179/185（96.8%），19 - 22岁为110/119（92.4%）。年龄较大、母亲教育水平低以及母亲为外籍与血清阴性相关（p<0.05）。麻疹 - 腮腺炎 - 风疹（MMR）疫苗计划有效诱导了风疹免疫力。然而，为消除先天性风疹综合征，应加大对易感青少年和年轻女性的疫苗接种力度。
